UV spectrophotometric method has been developed for simultaneous estimation of ciprofloxacin HCl (CIPRO) and bromhexine HCl (BROM) in their combined pharmaceutical dosage form. This method utilizes methanol as a solvent and λmax of ciprofloxacin HCl and bromhexine HCl selected for analysis was found to be 279 nm and 250 nm respectively. Linearity was observed for ciprofloxacin HCl and for bromhexine HCl in the concentration range of 2-12 μg/ml and (r2 = 0.999) and 5-30 μg/ml and (r2 = 0.993). The accuracy and precision were determined and found to comply with ICH guidelines. This method showed good reproducibility and recovery with % RSD in the desired range. The proposed methods can be successfully applied for the routine analysis of both the drugs in combined pharmaceutical dosage form. This method was simple, rapid, accurate and sensitive.
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